TB hotspots

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SequenceLDhot: detecting recombination hotspots

MOTIVATION There is much local variation in recombination rates across the human genome--with the majority of recombination occurring in recombination hotspots--short regions of around approximately 2 kb in length that have much higher recombination rates than neighbouring regions. Knowledge of this local variation is important, e.g. in the design and analysis of association studies for disease...

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ژورنال

عنوان ژورنال: Nature Reviews Immunology

سال: 2004

ISSN: 1474-1733,1474-1741

DOI: 10.1038/nri1342